Spider venom peptides for gene therapy of Chlamydia infection.
نویسندگان
چکیده
Spider venoms are vast natural pharmacopoeias selected by evolution. The venom of the ant spider Lachesana tarabaevi contains a wide variety of antimicrobial peptides. We tested six of them (latarcins 1, 2a, 3a, 4b, 5, and cytoinsectotoxin 1a) for their ability to suppress Chlamydia trachomatis infection. HEK293 cells were transfected with plasmid vectors harboring the genes of the selected peptides. Controlled expression of the transgenes led to a significant decrease of C. trachomatis viability inside the infected cells.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 55 11 شماره
صفحات -
تاریخ انتشار 2011